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How to take Avodart

Men often have problems with the prostate gland after the age of forty. The disease is manifested by pain in the lower abdomen, pain when urinating, frequent nocturnal urge to go to the toilet, as well as sexual dysfunction. To get rid of serious complications and discomfort, you need to be examined by a doctor and begin treatment. Nowadays, Avodart is widely used for prostatitis. The use of this remedy allows you to get rid of the disease at an early stage and return to normal life.

The medicine is prescribed for the treatment of prostatic hyperplasia. The drug belongs to 5-alpha-reductase inhibitors.

The medicine is made in the form of yellow gelatin capsules. The main substance in the composition is dutasteride at a dose of 500 mcg. Capsules are arranged in blisters of 10 pieces. The package may contain 3 and 9 plates with the medicine.

Action and Pharmacokinetics

The drug is used to treat benign prostatic hyperplasia. The main substance, dutasteride, helps testosterone to convert to dihydrotestosterone, which is the most important androgen that is responsible for hyperplasia of the glandular tissue of the prostate gland.

After taking one dose of the drug, the maximum concentration of the active ingredient is reached in plasma after 3 hours. Bioavailability does not depend on food intake and is 60% relative to intravenous infusion for 2 hours. Once in the body, dutasteride undergoes intensive metabolism. It is excreted through the kidneys and intestines. According to research, the drug can still be detected in the blood serum 6 months after the last intake.

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Indications and contraindications

The drug is used as an individual therapy for the treatment and prevention of benign prostatic hyperplasia. During treatment , the following improvements are observed:

  • The prostate gland decreases in size;
  • The symptoms of the disease pass;
  • Urination is improving;
  • Hypersensitivity to dutasteride and other components of the drug;
  • Children's age;
  • Renal and hepatic insufficiency;
  • The risk of acute urinary retention decreases, which is fraught with surgical intervention.

Avodart is also widely used in combination with alpha-blockers for the treatment of the prostate gland. Instructions, application, reviews - all this can be found in this article. Avodart is contraindicated for women.

Capsules should be taken orally, not chewed and washed down with a small amount of liquid. It is recommended to use one dose of 500 mcg per day for 6 months until a positive therapeutic effect is observed.

Basically, the drug is well tolerated. In rare cases , the following conditions may develop:

  • Angioedema;
  • Allergy;
  • Hypertrichosis;
  • Alopecia;
  • Mental disorder;
  • Depression.

The medicine should be stored at a temperature of no more than 30 degrees, out of the reach of children. With caution, you need to take the remedy for liver pathology. Taking dutasteride does not affect the driving of vehicles. Once every two months, it is necessary to undergo an examination and monitor the condition of the prostate gland. Before starting treatment, the drug instruction should be studied. Expert reviews show that side effects develop more often when the drug is taken incorrectly.

Avodart in the treatment of benign prostatic hyperplasia

In the process of aging, various processes occur in all organs and tissues, to varying degrees affecting their functional state and morphological structure. In some cases, this leads to a decrease in the function of organs and systems, in others - to the development of diseases not inherent in younger age groups. In women , age-related changes on the part of the genital organs lead to menopause with various hormonal disorders, involutional changes in the uterus and other genitals are accompanied by significant changes in the psycho-emotional sphere. The approximate temporary point of these changes is the disappearance of menstruation.

Men also experience various changes in the sexual sphere with age, but they are not so clearly defined in time and local manifestations. Thus, a decrease in the function of the sex glands, which is accompanied by a decrease in the level of testosterone in the peripheral blood, in men is not always accompanied by a weakening or the disappearance of sexual function as one of the manifestations of the normal hormonal background in men. Not always and in all men there is a change from other organs and systems associated with a decrease in the level of sex hormones. And since there is no clearly defined time period or any clinical manifestations of the beginning of this process of reducing the function of the genital glands, many of the clinical symptoms that have appeared are not associated with the aging of the male body.

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Simultaneously with the increase in age, benign growth of the prostate gland is noted. This process is based on hyperplasia of the tissue of the paraurethral glands and stromal elements of the central zone of the prostate gland. By itself, this process does not pose a threat to life, but complications from nearby organs significantly change the quality of life of an elderly person, which requires sufficiently long-term medication, and sometimes surgical treatment.

Frequency of benign prostatic hyperplasia (BPH) depends on the age of the man. It should be noted that in various studies, the values of the frequency of BPH at different ages vary, since in some cases these data are based on clinical studies, in others - on the results of pathomorphological studies of the prostate glands in deceased men of different ages. In five generalized pathomorphological studies of various age groups of male. It was noted that none of the studied under the age of thirty had signs of nodose hyperplasia. At the same time, half of men aged 50-60 years, and over the age of 80 years, 90% had BPH. There are no obvious epidemiologically unfavorable countries with regard to the incidence of BPH according to the results of various reviews.

The first histological signs of the disease can be detected by microscopic examination of the prostate glands already in thirty-year-old men. However, a clinically significant disease, which is determined by a standard clinical study (finger rectal examination, ultrasound, NMR), appears at a later age. By the age of 50, 50% of men already have BPH, which requires treatment in some of them.

Avodart (Dutasteride) reduces the progression of prostate cancer

The drug Avodart (Dutasteride) can inhibit the development of prostate cancer in the early stages, thereby reducing the need for aggressive therapy. This fact was revealed as a result of a new study of a drug for the treatment of prostatic hyperplasia. The American National Cancer Institute provides data that one in six men in the United States falls ill with prostate cancer.

Dutasteride suppresses the activity of 5-alpha reductase. As a result of clinical studies that lasted 3 years, its effectiveness in reducing the progression of prostate cancer was proven. Thus, in men with such a diagnosis, who took Avodart in the early stages, cancer continued to develop in 38% of the group of 144 people, and in those taking placebo - in 48% of the group of 145 people. Among the side effects were noted such as breast enlargement and sexual dysfunction.

"The word "cancer" for many patients is associated with instant radical measures," says Dr. Louis Potters, head of the Department of radiation Medicine at North Shore University Hospital. "Dutasteride therapy can serve as an alternative for these patients."

The use of 5-alpha reductase inhibitors for the treatment of patients causes an ambiguous reaction among scientists. The FDA recently announced that a drug in the course of prostate cancer therapy can provoke high-grade prostate cancer. "The value of such drugs will decrease significantly for urologists," said Ryan Terleki, doctor, associate professor of urology at Wake Forest Baptist Medical Center (North Carolina). Most likely, non-drug and non-invasive methods of treatment will replace it. One of them is the use of high temperature to eliminate the symptoms of prostate diseases".